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Common signs include: Dizziness or lightheadedness Extreme drowsiness or sedation Slow or irregular heartbeat Low blood pressure, which can cause fainting Confusion or difficulty staying awake Dry mouth and weakness In severe cases, respiratory depression or coma These symptoms occur because clonidine depresses the central nervous system and cardiovascular system

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Some people experience a brief return of appetite or mild GI effects when resuming after a gap, similar to what happens when restarting after a break with any GLP-1 medication